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Our pediatrician told us that it takes about 2 weeks for the majority of the drugs to leave their system an about another 2-4 weeks for the residual to move thorough on meth kids. We had an 18 month old foster child who tested positive and after 2 weeks we noticed a huge difference in him. He was moved to a relative after 3 weeks, but we were really beginning to see a marked improvement at that point.