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I agree with Nevada - if you research this, you'll find that the risk, depending on the degree of relationship, if smaller than most think. And we sometimes forget that there have to be specific genetic defects in the family tree (usually recessive, so they need one allele from the mother and the other from the father) for them to manifest. If there are none, they won't. That doesn't mean that something unexpected or spontaneous can't manifest, however.
I've seen my fair share of kids who were born as a product of in-family relationships, mostly with couples from South East Asia and the Middle East. All the kids I saw were products of first cousin relationships. Most had complex genetic disorders that were not well understood (one family had 4 kids, all of whom were affected to some degree). That said, in 3 years of residency training, I saw maybe 5 kids, and 3 of them were in the hospital literally every month.
I would do extensive research, and as aclee suggested, speaking to a genetics specialist (preferably pediatric) would be your best bet.