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I had a newborn on methadone. It's pretty easy, but they should give you an exact schedule for her taper. You need to be pretty good about always giving her it around the same time. We timed it according to when we'd usually be home so it worked well. Weird giving it to a tiny baby, but it's such a small amount. It took care of her extreme withdrawal symptoms (actually discharged her originally without it) but once we stopped it completely even with the slow taper, she was quite fussy for awhile and mild tremors returned. Poor babe. She was withdrawing from heroin.