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We had a baby on methadone last year. They said he was withdrawing from Rx meds. It was very rough because he screamed so much! It was a very intense, high pitched scream and was worst right before the next dose was due. He was also on an apnea machine that went off frequently and unnecessarily. Good luck with your little one, I hope she's easier. I don't know if we would take another baby on methadone.