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If one sibling is abusing the other and a therapist feels the risk is too much for them to heal together. Also, If there is a large distance between the children's ages, sometimes the older child will choose to enter independant living instead of being adopted. If one child has a problem that may sugnificantly lower the chances of ever being adopted if they stay together, or the sibs have different fathers and birth family is available for some and not the others. Those are the only ones I can think of right now.