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I think about those things too. If you laid out all the things that could possibly be passed on to mine and DH's bio children, it wouldn't look good. I suspect it's the same for most couples. I have a history of depression, Alzheimer's on both sides of my family, cancer, one of my DD's has congenital hypothyroidism (she was born with no thyroid gland) and a joint condition - she was in EI from birth-3 yrs, DH's mother's family has a history of addiction problems, we're both overweight. It's not pretty! But we have two beautiful, happy, healthy little girls with the result of those "bad" genes!
Kind of unrelated, but not a lot of families wanted to be shown for Caleb's situation because he was "gender unknown". That never made any sense to me. The only condition we knew about with him was his birthmom and a sibling have asthma, and yes, he developed asthma.